Fig. 3: CRS-related NE promotes the motility of epithelial ovarian cancers via the β-catenin/SLUG axis in nude mouse models and in vitro. | Cell Death & Disease

Fig. 3: CRS-related NE promotes the motility of epithelial ovarian cancers via the β-catenin/SLUG axis in nude mouse models and in vitro.

From: Melatonin suppresses chronic restraint stress-mediated metastasis of epithelial ovarian cancer via NE/AKT/β-catenin/SLUG axis

Fig. 3

a Content of NE in mouse serum and tumor tissues from the control group and the CRS group was evaluated by ELISA (n = 6). b Co-expression of β-catenin/NE in the tumor tissues obtained from animal models was examined by confocal laser scanning microscopy. CCK-8 assay was used to test the effects of different concentration of NE (c) and β-catenin inhibitor KYA1797K (e) on the viability of ovarian cancer cells at 24 h. d NE increased the expression of β-catenin and SLUG in ovarian cancer cells time-dependently. f Results from western blot showed that KYA inhibited NE-mediated upregulation of β-catenin and SLUG in ovarian cancer cells at 24 h. KYA reduced NE-induced pro-migration (g) and pro-invasion (h) effects on ovarian cancer cells at 24 h. *P < 0.05; **P < 0.01; ***P < 0.001. Scale bar, 200 μM.

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