Fig. 8: The putative signaling pathways of X-ray induced RGCs apoptosis by altering its mitochondrial dynamic balance. | Cell Death & Disease

Fig. 8: The putative signaling pathways of X-ray induced RGCs apoptosis by altering its mitochondrial dynamic balance.

From: Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy

Fig. 8: The putative signaling pathways of X-ray induced RGCs apoptosis by altering its mitochondrial dynamic balance.The alternative text for this image may have been generated using AI.

Radiation-induced optic neuropathy (RION) involves damage to the optic nerve, and mainly resulting in retinal ganglion cells (RGCs) injury. Cdk5 kinase activation is the trigger of the apoptotic process, resulting in Drp1 phosphorylation at serine 616. Increased p-Drp1 and then recruited and translocated from the cytoplasm to the outer mitochondrial membrane where it combines Fis1 and leads to mitochondrial division. A large number of ROS are produced simultaneously and results in RGCs apoptosis ultimately.

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