Fig. 5: BRD9 upregulates TUFT1 expression in HCC. | Cell Death & Disease

Fig. 5: BRD9 upregulates TUFT1 expression in HCC.

From: Bromodomain-containing protein 9 promotes the growth and metastasis of human hepatocellular carcinoma by activating the TUFT1/AKT pathway

Fig. 5: BRD9 upregulates TUFT1 expression in HCC.The alt text for this image may have been generated using AI.

a qRT-PCR was performed to determine the regulatory effect of BRD9 overexpression or knockdown on the TUFT1 level in Hep3B or HCCLM3 cells. n = three independent experiments, *P < 0.05 by t-test. b Western blotting was performed to determine the regulatory effect of BRD9 overexpression or knockdown on the TUFT1/AKT pathway in Hep3B or HCCLM3 cells. n = three independent experiments, *P < 0.05 by t-test. c The TCGA database was explored to evaluate the correlation between BRD9 and TUFT1 levels in HCC tissues. n = 374, *P < 0.05 by Spearman’s rank correlation test. d IHC was performed to evaluate the correlation between BRD9 protein and TUFT1 protein in the HCC tissues. Scale bar: 25 μm. n = 110, *P < 0.05 by t-test. e The positive rate of TUFT1 staining was compared between HCC tissues with positive and negative BRD9 staining. *P < 0.05 by Pearson χ2 test.

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