Fig. 7: Proposed model illustrating that miR-210-3p promotes the Warburg effect to facilitate tumor growth and avoid cell apoptosis. | Cell Death & Disease

Fig. 7: Proposed model illustrating that miR-210-3p promotes the Warburg effect to facilitate tumor growth and avoid cell apoptosis.

From: A miR-210-3p regulon that controls the Warburg effect by modulating HIF-1α and p53 activity in triple-negative breast cancer

Fig. 7

On the one hand, miR-210-3p targets GPD1L, which is known to maintain prolyl hydroxylase (PHD) activity; PHD is essential to hydroxylate pralines HIF-1α and leads to its degradation by the proteasome. On the other hand, miR-210-3p targets CYGB, which stabilize p53 in TNBC. Ultimately, miR-210-3p contributes to increased HIF-1α activity and decreased p53 activity in TNBC.

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