Fig. 3: A-485 inhibits the expression of lipogenesis-related genes in white adipose tissue. | Cell Death & Disease

Fig. 3: A-485 inhibits the expression of lipogenesis-related genes in white adipose tissue.

From: Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis

Fig. 3: A-485 inhibits the expression of lipogenesis-related genes in white adipose tissue.The alternative text for this image may have been generated using AI.

a Weight of epididymal white adipose tissue (eWAT) and inguinal white adipose tissue (iWAT) from mice treated with vehicle and A-485 for 7 days under normal chow diet (NCD) and high-fat diet (HFD) conditions. b Hematoxylin-eosin staining of iWAT and eWAT (bar = 100 μm). c Morphology of the iWAT and eWAT from HFD-fed mice treated with vehicle and A-485. d, e mRNA expressions of lipogenesis-related genes in the eWAT from NCD- and HFD-fed mice. f Western blot analysis of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) protein levels in the eWAT from NCD-fed mice. g mRNA expressions of fatty acid oxidation-related genes in the eWAT from NCD-mice. h, i Adiponectin, FABP4, and LPL mRNA expressions in the eWAT from NCD- and HFD-fed mice. j, k PPARγ and C/EBPα mRNA expressions in the eWAT from NCD- and HFD-fed mice. l PPARγ and C/EBPα protein expressions in the eWAT from NCD-mice. Data are expressed as means ± SEM (n = 5–9). *P < 0.05, **P < 0.01, ***P < 0.001 vs. vehicle group. #P < 0.05, ##P < 0.01 vs. HFD-vehicle group.

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