Fig. 7: BMSC-Exo with upregulated miR-193a and downregulated LRRC1 restrain migration and invasion while promote apoptosis of NSCLC cells, and suppress tumor growth in mice with NSCLC. | Cell Death & Disease

Fig. 7: BMSC-Exo with upregulated miR-193a and downregulated LRRC1 restrain migration and invasion while promote apoptosis of NSCLC cells, and suppress tumor growth in mice with NSCLC.

From: Bone marrow mesenchymal stem cells-derived exosomal microRNA-193a reduces cisplatin resistance of non-small cell lung cancer cells via targeting LRRC1

Fig. 7: BMSC-Exo with upregulated miR-193a and downregulated LRRC1 restrain migration and invasion while promote apoptosis of NSCLC cells, and suppress tumor growth in mice with NSCLC.The alternative text for this image may have been generated using AI.

a Effects of BMSC-Exo with upregulated miR-193a and downregulated LRRC1 on apoptosis of A549 and A549/DDP cells. b Effects of BMSC-Exo with upregulated miR-193a and downregulated LRRC1 on apoptosis of H1299 and H1299/DDP cells. c Impacts of BMSC-Exo with upregulated miR-193a and downregulated LRRC1 on invasion and migration abilities of A549 and A549/DDP cells. d Impacts of BMSC-Exo with upregulated miR-193a and downregulated LRRC1 on invasion and migration abilities of H1299 and H1299/DDP cells. e The effect of BMSC-Exo with upregulated miR-193a on tumorigenesis of A549 and A549/DDP cells. f The effect of BMSC-Exo with upregulated miR-193a on tumorigenesis of H1299 and H1299/DDP cells. *P < 0.05 vs. EXO-mimic-NC group. #P < 0.05 vs. EXO-si-NC group. &P < 0.05 vs. EXO-miR-193a inhibitor + si-NC group. Measurement data were depicted as mean ± standard deviation, comparisons between two groups were assessed by t-test while those among multiple groups by one-way ANOVA followed with Tukey’s multiple comparisons test, the experiment was repeated three times.

Back to article page