Fig. 2: ADT remodel PCa TIM. | Cell Death & Disease

Fig. 2: ADT remodel PCa TIM.

From: Immune signature driven by ADT-induced immune microenvironment remodeling in prostate cancer is correlated with recurrence-free survival and immune infiltration

Fig. 2: ADT remodel PCa TIM.

a Stromal and immune score and tumor purity calculated by ESTIMATE method in PCa and precancerous tissues pre- and post-ADT. b Expression of immune-related genes and immune checkpoint genes in PCa and paracancerous benign tissues pre- and post-ADT. c ssGSEA analysis identifying the relative infiltration of immune cell populations in PCa and precancerous tissues pre- and post-ADT. The relative infiltration of each cell type is normalized into a z score. d Correlation between infiltration of cell types executing antitumor immunity (activated dendritic cell, CD8 T cell, central memory T cell, cytotoxic cell, effector memory T cell, nature killer cell, NK CD56 bright cell, T cell, T-helper cell, Type 1 T-helper cell, and Type 17 T-helper cell) and cell types executing protumor, immune suppressive functions (immature dendritic cell, macrophages neutrophils, NK CD56 dim cell, regulatory T cell, and Type 2 T-helper cell) in PCa and precancerous tissues pre- and post-ADT. R coefficient of Pearson’s correlation. The shaded area represents 95% confidence interval. e Left: the expression of CD8 in samples with (43 patients) and without (22 patients) ADT (original magnification ×200).

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