Fig. 8: CPSI-1306 inhibits tumor growth, progression, and metastasis in the syngeneic orthotopic mouse model. | Cell Death & Disease

Fig. 8: CPSI-1306 inhibits tumor growth, progression, and metastasis in the syngeneic orthotopic mouse model.

From: Macrophage migration inhibitory factor inhibition as a novel therapeutic approach against triple-negative breast cancer

Fig. 8

a MVT-1 cells (5 × 105) were implanted into the fourth mammary gland of FVB mice (n = 5). Palpable tumors were treated with vehicle control (VC) or CPSI-1306 (10 mg and 20 mg/kg) five times in a week for up to 4 weeks. Representative tumor images are shown. b Tumor volumes (left) were measured externally every week during the CPSI-1306 treatment and tumor weight (right) was calculated after the termination of the study. c Vehicle or CPSI-1306-treated MVT-1-derived tumors were analyzed for apoptosis using TUNEL assay. d Representative photograph of lungs isolated from vehicle or CPSI-1306-treated groups. The bar graph represents the number of metastatic nodules in the lungs. The data reported mean ± SEM of triplicate experiments (*P < 0.05, **P < 0.01, ***P < 0.001, #non-significant).

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