Fig. 4: FAS knockdown promotes STAT3 phosphorylation. | Cell Death & Disease

Fig. 4: FAS knockdown promotes STAT3 phosphorylation.

From: miR-196b-5p-mediated downregulation of FAS promotes NSCLC progression by activating IL6-STAT3 signaling

Fig. 4: FAS knockdown promotes STAT3 phosphorylation.

a Western blot analyses for p-STAT3 (Y705), STAT3, p-Jak2, and Jak2 in FAS knockdown A549 and H292 lung cancer cells. The bands of p-STAT3 and p-Jak2 were quantified using Image J software, and relative values were obtained by normalizing to the value of each corresponding STAT3 and Jak2. b Western blot analysis to detect p-STAT3 (Y705) expression in FAS knockdown A549 and H292 lung cancer cells transfecting with or without STAT3 siRNAs. c Cell proliferation assay in FAS knockdown A549 and H292 lung cancer cells transfecting with or without STAT3 siRNAs. Results are represented as means ± SD (n = 3). *P < 0.05, **P < 0.01, ns no significance.

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