Fig. 6: A model for the mutual regulatory function of OGT and XIAP. | Cell Death & Disease

Fig. 6: A model for the mutual regulatory function of OGT and XIAP.

From: Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion

Fig. 6: A model for the mutual regulatory function of OGT and XIAP.

OGT mediates the O-GlcNAc modification of various target proteins and regulates various cellular processes, including oncogene expression. XIAP interacts with OGT and act as an E3 ubiquitin ligase for OGT. Expectedly, XIAP is also a substrate of OGT and O-GlcNAcylation of XIAP at serine 406 induces the polyubiquitination and degradation of OGT, leading to the inhibition of colon cancer cell growth and invasion.

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