Fig. 5: Day 30 DKO cerebral organoids show cortical disorganization and loss of cortical plate markers.
From: Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems
a Differentiation protocol from hiPSCs to day 30 cerebral organoids. b Day 30 DKO cerebral organoids derived from hiPSCs demonstrate reduced expression of SOX2, TBR1, and CTIP2. Scale bar = 100 µm. c Day 30 DKO cerebral organoids have reduced expression of PAX6, Reelin, and TBR2. Scale bar = 100 µm. All day 30 experiments were conducted after three independent differentiations.
