Fig. 7: DKO cerebral organoids have abnormal mitochondrial morphology.
From: Modeling the function of BAX and BAK in early human brain development using iPSC-derived systems
a DKO cerebral day 30 organoids stained with TOM20, TUJ1, and SOX2 show disorganized mitochondrial morphology in a 4 × 4 stitched image. Scale bar = 100 µm. b Higher magnification of cerebral day 30 organoids shows abnormal and aggregated mitochondria in DKO in a 3 × 3 stitched image. c Zoomed insert of control and DKO shows the intricate mitochondrial networks and the differences that are present. All day 30 experiments were conducted after three independent differentiations.
