Fig. 6: Schematic representation of PTPN14 aggravates inflammation in acute liver failure. | Cell Death & Disease

Fig. 6: Schematic representation of PTPN14 aggravates inflammation in acute liver failure.

From: PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure

Fig. 6: Schematic representation of PTPN14 aggravates inflammation in acute liver failure.

In the LPS+D-GalN-induced ALF mouse model, PTPN14 promoted SOCS7 degradation through ubiquitination at K11 and K48. Knockdown of SOCS7 facilitated the assembly of the IKK complex, thereby leading to the activation of NF-κB pathway and the excessive secretion of inflammatory factors.

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