Fig. 6: Overexpression of lncRNA Meg3 aggravated high glucose-induced mitochondrial fission and cell injuries in human podocytes. | Cell Death & Disease

Fig. 6: Overexpression of lncRNA Meg3 aggravated high glucose-induced mitochondrial fission and cell injuries in human podocytes.

From: Increased long noncoding RNA maternally expressed gene 3 contributes to podocyte injury induced by high glucose through regulation of mitochondrial fission

Fig. 6

a Expression of lncRNA Meg3 in Meg3 overexpression podocytes compared with the control. b Expression of Nephrin and Synaptopodin in human podocytes of different groups. c Representative structured of mitochondria of human podocytes were stained by MitoTracker Deep Red and imaged by laser scanning confocal microscopy (original magnification, ×630; scale bar, 10 μm). d Quantitative analyses of expression of Nephrin and Synaptopodin in human podocytes of different groups. e Quantitative analyses of mitochondrial organization on human podocytes from different groups (mean branch length, mean number of branches per network and mitochondrial footprint, n = 10 cells per group). Data were shown as mean ± SD in all statistical graphs. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 (n = 6 per group).

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