Fig. 1: AFP accelerates DEN-induced liver tumor progression in C3H mice.
From: AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway
a Liver tumor incidence in Afp-deficient (afp-/-; n = 24) and wild-type (wt, n = 32) C3H mice at 8 months after DEN injection. b Typical gross morphology of liver tumors from DEN-treated afp-/- or wt mice. c Representative microscopic features of HCC in hematoxylin and eosin (H&E)-stained liver sections from mice (Top, ×10 magnification; bottom, ×40 magnification; T: tumor; N: normal tissue). Scale bar, 100 μm. d Liver tumor numbers compared between afp-/- (n = 19) and wt (n = 24) mice. Data are expressed as the mean ± SD. e Sizes of liver tumors in afp-/- and wt mice. f Average maximal diameters of tumors compared between afp-/- and wt mice. *P < 0.05, **P < 0.01, and ***P < 0.001 versus wt mice.
