Fig. 8: MSC-exosome delivered miR-182-5p and miR-23a-3p to mitigate LPS-induced ALI and pulmonary fibrosis by targeting Ikbkb/Usp5 signaling. | Cell Death & Disease

Fig. 8: MSC-exosome delivered miR-182-5p and miR-23a-3p to mitigate LPS-induced ALI and pulmonary fibrosis by targeting Ikbkb/Usp5 signaling.

From: Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury

Fig. 8

a HE staining of lung tissues in four different groups (LPS, LPS + MSC-exosome, LPS + MSC-exosome+miR-23a-3p inhibitor, LPS + MSC-exosome+miR-23a-3p inhibitor+miR-182-5p inhibitor). Scale bar = 200 μm. b The concept map demonstrating the role and functional mechanism of MSC on alleviating ALI and pulmonary fibrosis. *p < 0.05, **p < 0.01.

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