Fig. 8: Schematic models showing the underlying mechanism by which GLUD2 T1492G variant modifies disease onset in the MPTP-induced PD animal model. | Cell Death & Disease

Fig. 8: Schematic models showing the underlying mechanism by which GLUD2 T1492G variant modifies disease onset in the MPTP-induced PD animal model.

From: Functional validation of a human GLUD2 variant in a murine model of Parkinson’s disease

Fig. 8

In this study, the T1492G variant of GLUD2 decreases glutamate transporters expression and function, induces apoptosis by decreasing Bcl-2 and increasing Bax expression, and reduces energy metabolism by decreasing succinate dehydrogenase activity. These effects cause glutamate excitotoxicity and succinic acid accumulation. Consequently, GLUD2 variant aggravates nigral dopaminergic neuron death and exacerbates movement deficits in MPTP-induced PD mice. In the schematic model, red arrows mean downregulate and green arrows mean upregulate.

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