Fig. 6: PTEN and TMEM127 are potential targets of METTL3/miR-17-92 cluster. | Cell Death & Disease

Fig. 6: PTEN and TMEM127 are potential targets of METTL3/miR-17-92 cluster.

From: N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer

Fig. 6

a Top 10 terms from miRNA functional enrichment of the miR-17-92 cluster. b KEGG analysis of the METTL3- and miR-17-92 cluster-regulated genes. (Upper) Number of potential target genes of the miR-17-92 cluster, METTL3-correlated genes, and their intersections. (Lower) Table with the KEGG results (pathways and involved genes) of the intersectional genes. c Correlation between METTL3 (y-axis) and PTEN or TMEM127 (x-axis) in the TCGA-STAD database. d Correlation between METTL3 (y-axis) and PTEN or TMEM127 (x-axis) in our clinical cohorts. e Genetic change of PTEN and TMEM127 in gastric cohorts from online databases. Original data were extracted from cBioPortal. FDR, false discovery rate adjusted P value.

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