Fig. 2: β2-AR and MEK1/2 inhibitors impair MAPK and PI3K pathways. | Cell Death & Disease

Fig. 2: β2-AR and MEK1/2 inhibitors impair MAPK and PI3K pathways.

From: β2-AR blockade potentiates MEK1/2 inhibitor effect on HNSCC by regulating the Nrf2-mediated defense mechanism

Fig. 2

a Immunoblot for ERK/ERKT202/Y2014, Nf-kB/Nf-kBS536, and p38/p38Y182 (below band densitometries); β2-AR blocking increases U0126 inhibition of ERK phosphorylation at a short time, the same trend is observed in Nf-kB. P38 phosphorylation is strongly reduced only over ICI treatment. b Immunoblot for mTOR/mTORS2448 and Akt/AKTS473 (below band densitometries); the Akt ratio between phosphorylated and non-phosphorylated forms decreases over ICI treatment, while U0126 has no effect; on the other hand, it increases ICI inhibition of mTOR phosphorylation (*P ≤ 0.05, **P ≤ 0.01, ****P ≤ 0.0001).

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