Fig. 2: Histological and western blotting analysis of NACHT-, LRR-, and pyrin (PYD)-domain-containing protein 3 (NLRP3) activation. | Cell Death & Disease

Fig. 2: Histological and western blotting analysis of NACHT-, LRR-, and pyrin (PYD)-domain-containing protein 3 (NLRP3) activation.

From: NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease

Fig. 2

A Immunofluorescence staining of NLRP3 and ionized calcium-binding adapter molecule 1 (Iba1) (×63 oil immersion objective). B Comparisons of NLRP3 intensities in the cortex and hippocampus. C Chemiluminescence images of NLRP3, caspase-1 and β-tubulin, IL-1β and β-actin. D Comparisons of the NLRP3/β-tubulin, cleaved caspase-1/β-tubulin, and IL-1β/β-actin ratios. Each dataset is expressed as mean ± SD. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. n = 6 mice.

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