Table 1 BMP4 overexpression ameliorates maternal diabetes-induced NTD.

From: Restoring BMP4 expression in vascular endothelial progenitors ameliorates maternal diabetes-induced apoptosis and neural tube defects

 

Experimental group

Glucose level (mg/dl)

Genotype

Embryos

NTDs Embryos (NTDs rate)

ND

Flk-1-Cre male x BMP4-Tg female (16 litters)

157.5 ± 7.6

non-BMP4-Tg

81

0

163 ± 11.78

BMP4-Tg

27

0

DM

Flk-1-Cre male x BMP4-Tg female (17litters)

476.5 ± 13.2

non-BMP4-Tg

87

21 (24.14%)a

432.56 ± 16.3

BMP4-Tg

31

2 (6.45%)

  1. The ratio of BMP4-Tg mice to non-BMP4-Tg mice is about 1 to 3. NTD rates in E10.5 embryos.
  2. ND nondiabetic, DM diabetes mellitus, BMP4-Tg BMP4 transgenic (Floxed BMP4; Flk-1-Cre+), non-BMP4-Tg non-BMP4 transgenic (include Wild-Type mice, Flk-1-Cre+ mice, and BMP4-Tg without Flk-1-Cre+).
  3. a Indicates significant difference (P < 0.05) when compared to other groups analyzed by the Fisher Exact test.
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