Fig. 2: Expression of miR-504 in GSCs and glial tumors. | Cell Death & Disease

Fig. 2: Expression of miR-504 in GSCs and glial tumors.

From: miR-504 modulates the stemness and mesenchymal transition of glioma stem cells and their interaction with microglia via delivery by extracellular vesicles

Fig. 2

Validation of top miRNAs enriched in GSCs (N = 11) compared with the hNSCs (N = 4) was performed by RT-PCR (A) P < 0.001. miR-504 expression in glial tumors compared with normal brains (n = 20 for each) was determined using real-time PCR (B) P < 0.001. Relative expression of miR-504 in GBM (C) and LGG (E) by subtypes was determined according to The Cancer Genome Atlas (TCGA data portal): gray bars indicate significant differences in post hoc t tests P < 0.05. Relative expression of miR-504 was also analyzed in grade III and grade II LGG (D). Overall survival plotted according to quartile of miR-504 expression among grade II and III glioma (F); log-rank P = 0.00136 overall; log-rank P = 0.00402, 0.00123, 0.0111, Q1 vs. Q2–4, respectively.

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