Fig. 4: Down-regulation of ClC-3/SGK1 axis attenuated olaparib-induced cell migration inhibition. | Cell Death & Disease

Fig. 4: Down-regulation of ClC-3/SGK1 axis attenuated olaparib-induced cell migration inhibition.

From: ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma

Fig. 4: Down-regulation of ClC-3/SGK1 axis attenuated olaparib-induced cell migration inhibition.The alt text for this image may have been generated using AI.

A, B Down-regulation of ClC-3/SGK1 axis attenuated olaparib-induced cell invasion and migration inhibition (n = 3). C Typical time courses of the chloride current recorded by whole-cell patch clamp. The results indicated that the chloride current activated by olaparib was decreased in ClC-3 KD SGC-7901 cells (n = 3). D Current density analysis indicated that the chloride current density activated by olaparib was decreased in ClC-3 KD SGC-7901 cells (n = 3). *P < 0.05.

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