Fig. 5: Up-regulation of ClC-3/SGK1 axis enhanced olaparib-induced cell growth inhibition. | Cell Death & Disease

Fig. 5: Up-regulation of ClC-3/SGK1 axis enhanced olaparib-induced cell growth inhibition.

From: ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma

Fig. 5: Up-regulation of ClC-3/SGK1 axis enhanced olaparib-induced cell growth inhibition.The alt text for this image may have been generated using AI.

A The protein levels of ClC-3 and SGK1 were significantly increased in the two ClC-3 OV cells treated with 20 μM olaparib (n = 3). vector empty vector-transfected cells, ClC-3 ClC-3 overexpression cells, ClC-3+shNC ClC-3 overexpression and SGK1 negative control cells, ClC-3+ shSGK1 ClC-3 overexpression and SGK1 knockdown cells. B, C Up-regulation of ClC-3/SGK1 axis enhanced olaparib-induced cell clonogenicity inhibition, and the enhancement effect could be attenuated by SGK1 KD (n = 3). D, E Up-regulation of ClC-3/SGK1 axis enhanced olaparib-induced cell cycle arrest at the G0/G1 phase, and the enhancement effect could be attenuated by SGK1 KD (n = 3). * P < 0.05.

Back to article page