Fig. 7: Schematic view of the degeneration of Atg7-knockout OHCs. | Cell Death & Disease

Fig. 7: Schematic view of the degeneration of Atg7-knockout OHCs.

From: Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice

Fig. 7: Schematic view of the degeneration of Atg7-knockout OHCs.

The upper panel shows the accelerated degeneration of Atg7-deficient OHCs. The lower panel shows control OHCs. Symbols are numbered as follows: (1) stereocilia; (2) disarrayed stereocilia; (3) kinocilium; (4) presynaptic ribbons; (5) sequestering membranes; (6) functional prestin; (7) malfunctional prestin; (8) MDV; (9) mitochondria; (10 and 11) abnormal mitochondria; (12) autophagic vacuoles; (13 and 14) partially enwrapped mitochondria; (15 and 16) fully enwrapped mitochondria; (17) aging mitochondria.

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