Fig. 4: BCL11B inhibits cell proliferation and cell self-renewal capacities in vivo. | Cell Death & Disease

Fig. 4: BCL11B inhibits cell proliferation and cell self-renewal capacities in vivo.

From: BCL11B suppresses tumor progression and stem cell traits in hepatocellular carcinoma by restoring p53 signaling activity

Fig. 4

a Knockdown of BCL11B in MHCC97L cells markedly promoted tumor growth in vivo according to orthotopic xenograft models. b Overexpression of BCL11B in Huh7 cells greatly inhibited tumor growth according to orthotopic xenograft models. c Nude mice injected with serially diluted BCL11B-knockdown MHCC97L cells (102, 103, 104, and 105) as well as corresponding parental cells to evaluate the effects of BCL11B expression on tumor initiation ability. d Nude mice injected with serially diluted BCL11B-overexpressing Huh7 cells (102, 103, 104, and 105) as well as corresponding parental cells to evaluate the effects of BCL11B expression on tumor initiation ability. e Expression states of cell proliferation (Ki67), cell stemness (CD24) and mature hepatocyte (CK8) markers were evaluated by IHC staining; *P < 0.05; **P < 0.01; ***P < 0.001.

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