Fig. 2: The ALS/FTLD causative genes co-aggregated with TDP-43 induce cytoplasmic translocation of wild-type TDP-43. | Cell Death & Disease

Fig. 2: The ALS/FTLD causative genes co-aggregated with TDP-43 induce cytoplasmic translocation of wild-type TDP-43.

From: Aggresome formation and liquid–liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43

Fig. 2

A Representative images of the screening results with N2a cells stably expressing EGFP-fused wild-type TDP-43 (TDP-43WT). Arrowheads indicate cytoplasmic co-aggregates of the Group 1 gene products and TDP-43WT. Scale bars = 20 µm. B The summary of the TDP-43 co-aggregation screening. The genes in Group 1 were further classified into two subgroups based on their physiological functions: microtubule-related proteins (MRPs) and RNA-binding proteins (RBPs).

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