Fig. 5: The miR-30a-5p/CLCF1 axis regulates tumorigenesis and sorafenib resistance in HCC cells resistant to sorafenib. | Cell Death & Disease

Fig. 5: The miR-30a-5p/CLCF1 axis regulates tumorigenesis and sorafenib resistance in HCC cells resistant to sorafenib.

From: RETRACTED ARTICLE: The miR-30a-5p/CLCF1 axis regulates sorafenib resistance and aerobic glycolysis in hepatocellular carcinoma

Fig. 5

a HepG2-S-R cells transfected with miR-30a-5p with or without CLCF1 cotransfection were treated with increasing dose sorafenib for 72 h. Relative cell viability was analyzed by MTT. The significance of the difference in IC50 values was analyzed by extra sum-of-squares F test. b Western blotting of indicated proteins in HepG2-S-R cells transfected with miR-30a-5p with or without CLCF1 cotransfection. c The growth of HepG2-S-R tumors in mice is controlled by the miR-30a-5p/CLCF1 axis. d Paraffin-embedded sections of HepG2-S-R tumor tissues from mice treated as in (a) were analyzed by IHC staining for Ki-67, or IF staining for cleaved caspase 3. Scale bars: 25 µm.

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