Fig. 8: Diagram of the mechanism of PDT inducing autophagy and apoptosis in CRC cells. | Cell Death & Disease

Fig. 8: Diagram of the mechanism of PDT inducing autophagy and apoptosis in CRC cells.

From: Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway

Fig. 8

M-THPC-PDT or VP-PDT treatment results in ROS accumulation, which induced autophagy and apoptosis in CRC cells, through regulating JNK and mTOR pathways. Moreover, NAC, SP600125, or siATG5/siATG7 can inhibit autophagy, which reduces the apoptosis induced by PDT.

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