Fig. 3: Pathogenic role of the brain-gut-microbiota axis dysfunction during inflammaging.
From: Age-related cerebral small vessel disease and inflammaging
In the process of inflammaging, gastrointestinal mucosa and blood-brain barrier (BBB) function are impaired, and the brain-gut-microbiota axis function is disturbed. Pathogenic microbiota and their products (LPS, amyloid proteins, and various microbial exudates) can further induce inflammatory responses and dysfunction of the brain-gut-microbiota axis, ultimately leading to the neuropathic diseases with the amyloidogenic component.
