Fig. 1: MiR-671 was upregulated in metastatic PCa tissues.
From: MiRNA-671-5p Promotes prostate cancer development and metastasis by targeting NFIA/CRYAB axis
A The flow chart of bioinformatics analysis for screening miRNAs associated with PCa metastasis. B The expression profile of 22 DE-miRNAs in GSE21036. C, D The expression levels of miR-671 increased steadily from adjacent normal tissues, primary localized PCa tissues, to metastatic PCa tissues in GSE21036 and TCGA. E MiR-671 expression levels was upregulated in 44 paired PCa tissues compared with that in the matching adjacent normal tissues in TCGA. F, G Real-time PCR analysis of miR-671 expression in 10 paired PCa tissues. H Real-time PCR analysis of miR-671 expression in normal prostate epithelial cell (RWPE-1) and 6 PCa cells. The data were presented as means ± SD from three biological replicates. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; Student’s t-test (C, D, H); paired t-test (E, G). ANT, adjacent normal tissues; P or PPCa, primary localized PCa tissues; M or MPCa, metastatic PCa tissues; T, tumor tissues; DE-miRNAs, differentially expressed miRNAs.
