Fig. 5: MiR-671 promoted tumor development and metastasis via downregulating of NFIA.
From: MiRNA-671-5p Promotes prostate cancer development and metastasis by targeting NFIA/CRYAB axis
A, B Three siRNAs were designed to suppress NFIA expression, and si-NFIA #2 was chosen for the subsequent experiments due to the highest inhibitory efficiency. C, D Promotive effect on proliferation, migration, and invasion in PC-3 cells after Knockdown of NFIA expression. E NFIA protein expression in rescue experiment of NFIA overexpression in cells with stable miR-671 overexpression and corresponding control cells. F–H The proliferative, migratory, and invasive abilities of PC-3 cells impaired after upregulating NFIA, and the carcinogenesis effect of miR-671 could also be reversed. The data were presented as means ± SD from three biological replicates. **P < 0.01; ***P < 0.001; ****P < 0.0001; Student’s t-test.
