Fig. 3: The absence of Parp3 causes oxidative stress and mitochondrial dysfunction in NPSC and astrocytes. | Cell Death & Disease

Fig. 3: The absence of Parp3 causes oxidative stress and mitochondrial dysfunction in NPSC and astrocytes.

From: Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation

Fig. 3

a Measurement of total ROS production in NPSCs and throughout astrocyte differentiation (d1-d12) in Parp3+/+ versus Parp3–/– cultures. Values represent means ± s.d. of three biological replicates and two independent clones. *P < 0.05, **P < 0.01, ***P < 0.001. b Measurement of mitochondrial ROS production in NPSCs and throughout differentiation (d1-d12) in Parp3+/+ versus Parp3–/– cultures. Values represent means ± s.d. of three biological replicates and two independent clones. *P < 0.05, **P < 0.01. c Measurement of mitochondrial membrane potential in NPSC and astrocytes (d4, d6) in Parp3+/+ versus Parp3–/– cultures. Values represent means ± s.d. of three biological replicates and two independent clones. **P < 0.01, ***P < 0.001.

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