Fig. 2: UBP310 rescues the loss of SNc DA neurons in parkinQ311X mice. | Cell Death & Disease

Fig. 2: UBP310 rescues the loss of SNc DA neurons in parkinQ311X mice.

From: Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity

Fig. 2

Representative images showing TH immunoperoxidase labeling in the SNc of the WT and the parkinQ311X mice (6 months of age) treated with either vehicle or UBP310 (20 mg/kg i.p.) for 90 or 135 days. The graph below the picture shows DA neuron quantification performed by stereological count. Data are the means ± SEM of TH-positive neurons: WT treated with vehicle for 90 days 5578 ± 235 n = 8 mice, WT treated with UBP310 for 90 days 5351 ± 162 n = 7 mice, parkinQ311X treated with vehicle for 90 days 4701 ± 117 n = 11 mice, parkinQ311X treated with UBP310 for 90 days 5347 ± 107 n = 12 mice, parkinQ311X mice treated with UBP310 for 135 days 5514 ± 94 n = 9 mice, one-way ANOVA followed by Tukey’s test F = 6.681, WT vehicle 90 days vs. parkinQ311X vehicle 90 days ***p = 0.0007, WT UBP310 90 days vs. parkinQ311X vehicle 90 days *p = 0.0260, parkinQ311X vehicle 90 days vs. parkinQ311X UBP310 90 days **p = 0.0073, parkinQ311X vehicle 90 days vs. parkinQ311X UBP310 135 days **p = 0.0012.

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