Fig. 4: Cytotoxicity results of MDA-MB-231 breast cancer cell SKOV3 ovarian cancer cell co-encapsulations with CD8+ T cells. | Cell Death & Disease

Fig. 4: Cytotoxicity results of MDA-MB-231 breast cancer cell SKOV3 ovarian cancer cell co-encapsulations with CD8+ T cells.

From: Quantifying the efficacy of checkpoint inhibitors on CD8+ cytotoxic T cells for immunotherapeutic applications via single-cell interaction

Fig. 4

A–C Target cell is MDA-MB-231. A Cytotoxicity of each treatment at multiple timepoints normalized to control. The number of repeats (n) for each condition is PD1: 4, LAG3: 4, PD1+ LAG3: 3. Error bars represent the standard error from the mean. B Serial-killing potential of CD8+ T cells paired with two target cells. Events (droplets) observed for each condition are: Control: 37, PD1: 35, LAG3: 24, PD1+ LAG3: 32. C Target cell time of death analysis for 50 randomly selected cells from droplet co-encapsulations each treatment condition. D–F Target cell is SKOV3. D Normalized cytotoxicity over multiple timepoints normalized to control. The number of repeats (n) for each condition is PD1: 4, LAG3: 4, PD1+ LAG3: 3. E Serial-killing potential. Events (droplets observed of each condition) are: Control: 25, PD1: 10, LAG3: 25, PD1+ LAG3: 12. F Time of death analysis of 40 randomly selected cells. Error bars represent a 95% confidence interval of the mean.

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