Fig. 2: Knockdown of YTHDC1 exacerbates ischemic brain injury. | Cell Death & Disease

Fig. 2: Knockdown of YTHDC1 exacerbates ischemic brain injury.

From: YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA

Fig. 2: Knockdown of YTHDC1 exacerbates ischemic brain injury.The alternative text for this image may have been generated using AI.

A Representative immunoblot and quantification (B) of YTHDC1 in corresponding rat brain tissues before ischemia or after ischemia after injection with shNC or shYTHDC1 lentivirus for 2 weeks. β-actin served as a loading control. C TTC-stained sections from shNC or shYTHDC1-injected rats at 24 and 48 h after tMCAO. D, E Quantification of the infarct volume (D) and neurological deficit score (E) after MCAO. n = 5–7. The data are means ± S.E.M., for all panels: *P < 0.05, **P < 0.01, ***P < 0.001 by two-way ANOVA analysis. All data are representative of or combined from at least three independent experiments.

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