Fig. 7: Identification of the positive-feedback loop in STAT3–TINCR–EGFR signaling axis. | Cell Death & Disease

Fig. 7: Identification of the positive-feedback loop in STAT3–TINCR–EGFR signaling axis.

From: LncRNA TINCR favors tumorigenesis via STAT3–TINCR–EGFR-feedback loop by recruiting DNMT1 and acting as a competing endogenous RNA in human breast cancer

Fig. 7

a Upper corner of picture: STAT3-binding motif; lower table: prediction of STAT3-binding sites within TINCR promoter region, from JASPAR database. b Enrichment peak of STAT3 in the promoter of TINCR in ChIP-seq of HCC70 cells in ENCODE database. c TINCR expression is positively correlated with STAT3 mRNA expression in 1019 cancer cell lines in CCLE cohort. d STAT3 knockdown decreases TINCR expression in MBA-MB-231 cells. e ChIP assay results indicating STAT3 enrichment at TINCR promoter and diminished STAT3 enrichment at the promoter after STAT3 knockdown. f Molecular mechanism of dual regulation by TINCR of EGFR and its downstream genes. Data are presented as means from three independent experiments ± S.D. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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