Fig. 5: The effect of FATP2 inhibitor on profibrotic cytokines in vivo and in vitro.
From: Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis
a TGF-β, p-Smad2, and p-Smad3 and GAPDH protein by immunoblot in UUO mouse samples. GAPDH sets as loading control. Schematic representation of quantitative data of indicated proteins. b TGF-β, p-Smad2, and p-Smad3and GAPDH protein by immunoblot in HK-2 cells. GAPDH sets as loading control. Schematic representation of quantitative data of indicated proteins. c, e Profibrotic cytokines TGF-β, Ctgf, Fgf2, Pdgfb mRNA expression by RT-qPCR analysis in UUO mouse. d, f Profibrotic cytokines TGF-β, Ctgf, Fgf2, Pdgfb mRNA expression by RT-qPCR analysis in HK-2 cells. Representative images from three independent experiments are shown above. n = 6 mice per group. *P < 0.05.
