Fig. 9: Schematic representation of the proposed molecular mechanism. | Cell Death & Disease

Fig. 9: Schematic representation of the proposed molecular mechanism.

From: Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons

Fig. 9

CRHR1 activation triggers a signaling cascade leading to the activation of Nf-KB and increased iNOS activity. This eventually leads to increased phospshporylation and nytrosilation of DRP1, which drives the morphological and bioenergetics alterations of mitochondria upon CRH exposure.

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