Table 1 Univariate and multivariate analyses for OS and recurrence-free survival of ECC patients.
From: BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways
Characteristic | OS | Recurrence-free survival | ||
|---|---|---|---|---|
P value | HR (95% CI) | P value | HR (95% CI) | |
Univariate analysis | ||||
 Age (>60 vs. ≤60) | 0.191 | 1.327 (0.868–2.029) | 0.124 | 1.424 (0.907–2.236) |
 Sex (male vs. female) | 0.325 | 0.801 (0.515–1.246) | 0.043 | 0.61 (0.378–0.985) |
 CA19-9 (≥200 vs. <200 U/ml) | 0.803 | 1.073 (0.615–1.875) | 0.521 | 1.21 (0.676–2.166) |
 Tumor size (>3 vs. ≤3 cm) | 0.719 | 1.091 (0.679–1.751) | 0.873 | 1.042 (0.63–1.722) |
 Perineural invasion (yes vs. no) | 0.031 | 1.677 (1.049–2.681) | 0.106 | 1.494 (0.918–2.431) |
 Lymph node invasion (yes vs. no) | 0.011 | 1.732 (1.137–2.637) | 0.012 | 1.793 (1.137–2.828) |
 Tumor thrombus (yes vs. no) | 0.044 | 2.003 (1.02–3.931) | 0.658 | 1.193 (0.545–2.614) |
 TNM stage (III–IV vs. I–II) | 0.066 | 1.531 (0.973–2.411) | 0.009 | 1.881 (1.168–3.029) |
 R0 resection (yes vs. no) | 0.012 | 1.951 (1.16–3.28) | 0.011 | 2.004 (1.171–3.431) |
 BUB1B expression (high vs. low) | 0.002 | 2.111 (1.322– 3.372) | 0.005 | 2.036 (1.235–3.356) |
Multivariate analysis | ||||
 BUB1B expression | 0.003 | 2.163 (1.302–3.593) | 0.002 | 2.374 (1.378–4.088) |
 R0 resection |  |  | 0.011 | 2.070 (1.178–3.637) |
 Sex |  |  | 0.01 | 0.501 (0.297–0.845) |
 Lymph node invasion | 0.014 | 1.754 (1.120–2.748) |  |  |
 TNM stage |  |  | 0.01 | 1.961 (1.177–3.268) |
 Perineural invasion | 0.047 | 1.677 (1.302–3.593) |  |  |
