Fig. 6: circXPO1 promotes LUAD tumor growth in vivo and is a potential therapeutic target.
From: A novel circular RNA, circXPO1, promotes lung adenocarcinoma progression by interacting with IGF2BP1
Xenograft tumor models were established using SPC-A1 cells transfected with negative control siRNA and si-circXPO1. Tumor size (a), growth curve of tumor volume (b), and tumor weight (c) were accessed for each derived xenograft tumor. Patient-derived xenograft (PDX) models were established and each tumor was intratumourally injected with negative control siRNA or si-circXPO1. Tumor size (d), growth curve of tumor volume (d), and tumor weight (f) were accessed for each tumor. Schematic diagram of the role of circXPO1 role in LUAD (f). XPO1 gene amplification leads to increased expression of circXPO1, and circXPO1 binds to IGF2BP1, enhancing CTNNB1 mRNA stability, thus increasing the CTNNB1 repression and promoting LUAD progression. (P values were calculated by non-paired student tests. *P < 0.05, **P < 0.01. The error bars indicate the standard deviations.).
