Fig. 1: Hepatic Cnr1 regulates liver disease-associated genes. | Cell Death & Disease

Fig. 1: Hepatic Cnr1 regulates liver disease-associated genes.

From: Hepatocyte cannabinoid 1 receptor nullification alleviates toxin-induced liver damage via NF-κB signaling

Fig. 1

Gene expression using RNA extracted from isolated hepatocytes of hCNR1+/+ and hCNR1−/− mice (n = 3). A CB1R mRNA (Cnr1) expression in hepatocytes isolated from hCNR1+/+ and hCNR1−/− mice. B Heat map of genome-wide expression changes by normalized z-score between −1.74 and 1.74. C Gene ontology (GO) analysis on liver disease-related genes based on genome-wide expression changes by normalized z-score between −1.74 and 1.74 depicted in B. Bubble sizes depict number of genes associated with hepatitis category. D Fold change of genes that are inflammation associated in hCNR−/− mice compared to hCNR+/+ mice. E Fold change of genes that are liver-disease associated in hCNR−/− mice compared to hCNR1+/+ mice. Heat map showing z-score (−2.0 and 2.0) of the nine identified present in the GO pathway associated with liver damage inflammation. F Fold change of inflammatory cytokines and growth factors in hCNR−/− mice compared to hCNR1+/+ mice.

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