Fig. 2: Nullification of hepatic CB1R ameliorates liver damage via anti-apoptotic signaling. | Cell Death & Disease

Fig. 2: Nullification of hepatic CB1R ameliorates liver damage via anti-apoptotic signaling.

From: Hepatocyte cannabinoid 1 receptor nullification alleviates toxin-induced liver damage via NF-κB signaling

Fig. 2: Nullification of hepatic CB1R ameliorates liver damage via anti-apoptotic signaling.

A Cnr1 in liver from hCNR1+/+ and hCNR1−/− mice with or without Con A (5 mg/kg) injection (n = 4–5) for 12 h. B Plasma alanine aminotransferase (ALT) levels (IU/L) in Con A-administered hCNR1+/+ and hCNR1−/− mice (n = 6 per each group). C–E H&E staining (×10 (left, scale bars, 200 μm) and ×40 (right, scale bars, 100 μm) magnifications) and quantifications of the percentage of the average area of inflammatory cells inflammation (D) and hepatocyte necrosis (E) after 5 mg/kg of Con A administration for 12 h. F Protein expression levels in liver tissue lysates post-injection of 5 mg/kg of Con A administration for 12 h (n = 4) and quantification for cleaved caspase 3 (G) and poly (ADP-ribose) polymerase (PARP) (H). Values were normalized to β-tubulin. Results were expressed as mean ± S.E.M. (*p ≤ 0.05, **p ≤ 0.01, ****p ≤ 0.0001 compared to Control; #p ≤ 0.05, ##p ≤ 0.01, ###p ≤ 0.001 compared to hCNR1+/++Con A).

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