Fig. 4: Effects of kcnq1ot1 on cholesterol transporter and receptor expression. | Cell Death & Disease

Fig. 4: Effects of kcnq1ot1 on cholesterol transporter and receptor expression.

From: LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis

Fig. 4

A, B The mRNA and protein levels of ABCA1, ABCG1, CD36, and SR-A in the aorta from apoE−/− mice were assayed by qRT-PCR and western blot, respectively (n = 10). C, D qRT-PCR and western blot analyses of ABCA1, ABCG1, CD36 and SR-A expression in MPMs from apoE−/− mice (n = 5). E, F After treatment of THP-1 macrophages with PBS, LV-NC or LV-kcnq1ot1 for 72 h, both qRT-PCR and western blot were employed for detection of ABCA1, ABCG1, CD36, and SR-A expressions. Data are represented as mean ± SD. ***P < 0.001; ns not significant.

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