Fig. 5: Salubrinal impeded fatty degeneration in HepG2 cells. | Cell Death & Disease

Fig. 5: Salubrinal impeded fatty degeneration in HepG2 cells.

From: Phosphorylation of eIF2α signaling pathway attenuates obesity-induced non-alcoholic fatty liver disease in an ER stress and autophagy-dependent manner

Fig. 5

a, b Representative oil red O staining images showing salubrinal effects in HepG2 cells and quantitative analysis by OD520 (200×; scale bar = 100 μm; all graphics were processed in a blinded fashion). c Representative images of Western blot for the selected genes involved in the ER stress in HepG2 cells (p-eIF2α, ATF4, and CHOP) and autophagy (LC3 and p62). d–h Relative intensities of p-eIF2α/eIF2α (d), ATF4 (e), CHOP (f), LC3II/I (g), and p62 (h). The experiments were conducted in triplicate. The asterisks (*, **, and ***) represent P < 0.05, P < 0.01, and P < 0.001, respectively (S: salubrinal and OA: oleic acid).

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