Fig. 3: Hepatic and splenic DCs exhibited an immature phenotype in BDL-induced liver fibrosis.

A Activation marker expression on hepatic DCs in sham, operated mice were measured by flow cytometry and summarized data were listed on right (B) (n ≥ 3). C Representative FACS plots showing CD11c⁺CD80⁺, CD11c⁺CD86⁺, CD11c⁺MHCII⁺, and CD11c⁺CD40⁺ cells in WT control, WT model mice and summarized data were listed on right (D) (n ≥ 3). E Frequencies of CD3⁺, CD3⁺CD4⁺, CD3⁺CD8⁺ T cells in hepatic NPCs were assessed by flow cytometry and summarized data were listed on right (G) (n ≥ 3). F MFI of CD3, CD4, CD8a in hepatic NPCs were measured by flow cytometry and summarized data were listed on right (H) (n ≥ 3). The data are presented as the means ± SEM. P < 0.05 is considered statistically significant. Statistical analysis was analyzed by independent-samples t-test.