Fig. 5: Deficiency of IDO1 helped to promote hepatic, splenic DCs maturation in response to liver fibrosis induced by BDL. | Cell Death & Disease

Fig. 5: Deficiency of IDO1 helped to promote hepatic, splenic DCs maturation in response to liver fibrosis induced by BDL.

From: Indoleamine 2,3-dioxygenase 1 limits hepatic inflammatory cells recruitment and promotes bile duct ligation-induced liver fibrosis

Fig. 5

A Frequencies of hepatic CD11c+CD80+, CD11c+CD86+, CD11c+MHCII+, and CD11c+CD40+ cells in WT and IDO1−/− mice was determined by flow cytometry and summarized data were listed on right (B) (n ≥ 3). C Activation marker expression on hepatic DCs in WT and IDO1−/− mice were measured by flow cytometry and summarized data were listed on right (D) (n ≥ 3). E Frequencies of CD3+, CD3+CD4+, CD3+CD8+ T cells in hepatic NPCs were assessed by flow cytometry and summarized data were listed on right (G) (n ≥ 3). F MFI of CD3, CD4, CD8a in hepatic NPCs were measured by flow cytometry and summarized data were listed on right (H) (n ≥ 3). The data are presented as the means ± SEM. P < 0.05 is considered statistically significant. Statistical analysis was analyzed by independent-samples t-test.

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