Fig. 5: IL-38 reduces cytokine and chemokine production during poly(I:C)-induced lung injury.

Serum and lung homogenates (n = 3–5 each group) were collected on day 1, 4, and 7 after poly(I:C) injection. Each symbol represents an individual mouse. Specific cytokines and chemokines in the serum (a–h) and lung (I–P) were measured with Mouse Cytokine Milliplex MAP assay kit or LEGENDplex™ kits at indicated times, respectively. Bars represent the mean from at least three different experiments (± SEM). Mann–Whitney test was used to compare the differences between groups. *p < 0.05, **p < 0.01, and ***p < 0.001.