Table 1 Par-4 interacting proteins.
From: Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore
Protein | Interaction | Domain | Ref |
|---|---|---|---|
AATF/Che-1 | Inhibits Par-4-mediated processing of β-amyloid precursor protein | LZ | |
Akt | Phosphorylates and sequesters Par-4 in the cytoplasm and blocks apoptosis | LZ, Thr163 | |
Amida | Recruits Amida to actin cytoskeleton, leading to the induction of apoptosis | LZ | |
aPKC | Inhibits the activity of PKCζ, thereby inhibits PKCζ-mediated promotion of NF-κB activity | LZ | |
BACE1 | Directly regulates amyloid precursor protein cleavage activity of BACE1 | LZ | |
CK-2 | Impairs the pro-apoptotic activity of Par-4 | Ser231 | |
D2DR | Facilitates Ca2+-mediated downregulation of D2DR efficacy and signaling | LZ | |
DAPK3 | Relocates DAPK3 from the nucleus to the cytoplasm, particularly to actin filaments | LZ | |
E2F1 | Indirectly controls the transcription of Smac gene through interacting with E2F1 | LZ | |
Fbxo45 | Promotes ubiquitylation and proteasomal degradation of Par-4 | VASA | |
PKA | Promotes nuclear translocation of Par-4 and induces apoptosis | Ser228 | |
SQSTM1/p62 | Antagonizes Par-4-mediated inhibition of PKCζ by forming a ternary complex | LZ | |
THAP1 | Potentiates both serum withdrawal- and TNFα-induced apoptosis | LZ | |
TOP1 | Sequesters TOP1, attenuating its DNA relaxing catalytic activity | LZ | |
TRIM21 | Down-regulates Par-4 and promotes cancer survival | NA | |
UACA | Prevents Par-4-mediated translocation of GRP78 from the ER to the cell surface | NA | |
Vimentin | Sequesters Par-4 preventing its secretion and extracellular function | NA | |
WT1 | Repress WT1 and negatively modulates its transcription of Bcl-2, thereby induces apoptosis | LZ |
