Table 2 Various stimuli inducing Par-4 and their mode of cell death.
From: Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore
Stimulus | Model system | Response | Ref |
|---|---|---|---|
3-azidowithaferin A | HeLa and PC3 | ↓Invasion and angiogenesis | |
3-azidowithaferin A | MCF7 and DU145 | ↓EMT and invasion | |
All-trans-retinoid acid | LNln3 | ↑Apoptosis | |
Arsenic trioxide | U87MG and U118MG | ↑Autophagy | |
Ceramide | U87MG and U118MG | ↑Autophagy | |
COX inhibitors | HCA-7 | ↑Apoptosis | |
Cranberry | DU145 | ↑Apoptosis | |
Curcumin | U87MG and U118MG | ↑Autophagy | |
Docetaxel | MCF7 | ↑Apoptosis | |
Doxorubicin | Jurkat | ↑Apoptosis | |
Imatinib | DOHH-2 and WSU-NHL | ↑Apoptosis | |
ISC-4 | Nude Mouse | ↑Tumor reduction | |
Lapatinib | BT-474 | Improve survival | |
Ouabain | PC3 | ↑Apoptosis | |
Parasporin-2Aa1 | PC3 | ↑Apoptosis | |
Raloxifene | EPN | ↑Apoptosis | |
Sanguinarine | PC3 and DU145 | ↑Apoptosis | |
Tamoxifen | HNGC-2 | ↑Apoptosis | |
Thymoquinone | U87MG | ↑Senescence | |
Withaferin A | PC3 | ↑Apoptosis |
